New research isolates the activity of individual nerve cells during the act of smelling, with important implications for our understanding of odour perception (words: the University of Bonn)
We often only realize how important our sense of smell is when it is no longer there: food hardly tastes good, or we no longer react to dangers such as the smell of smoke. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the University of Aachen are investigating the neuronal mechanisms of human odour perception, and appear to have pinpointed individual nerve cells in the brain that recognize odours and react specifically to the smell, the image and the written word of an object, such as a banana. The results of the study are said to close a long-standing knowledge gap in animal and human odour research and have been published in the journal Nature.
Imaging techniques such as functional magnetic resonance imaging (fMRI) have previously revealed which regions of the human brain are involved in olfactory perception. However, these methods do not allow the sense of smell to be investigated at the fundamental level of individual nerve cells. “Therefore, our understanding of odour processing at the cellular level is mainly based on animal studies, and it has not been clear to what extent these results can be transferred to humans,” says co-corresponding author Prof. Florian Mormann from the Department of Epileptology at the UKB.
Nerve cells identify odours
Mormann’s research group has now succeeded for the first time in recording the activity of individual nerve cells during smelling. This was only possible because the researchers worked together with patients from the Clinic for Epileptology at the UKB, one of the largest epilepsy centres in Europe, who had electrodes implanted in their brains for diagnostic purposes. They were presented with both pleasant and unpleasant scents, such as old fish. “We discovered that individual nerve cells in the human brain react to odours. Based on their activity, we were able to precisely predict which scent was being smelled,” says first author Marcel Kehl, a doctoral student at the University of Bonn.
The measurements showed that different brain regions such as the primary olfactory cortex, anatomically known as the piriform cortex, and also certain areas of the medial temporal lobe, specifically the amygdala, the hippocampus and the entorhinal cortex, are involved in specific tasks. While the activity of nerve cells in the olfactory cortex most accurately predicted which scent was smelled, neuronal activity in the hippocampus was able to predict whether scents were correctly identified. Only nerve cells in the amygdala, a region involved in emotional processing, reacted differently depending on whether a scent was perceived as pleasant or unpleasant.
Words are enough
Next, the group investigated the connection between the perception of scents and images. To do this, they presented the participants in the Bonn study with the matching images for each odour, for example the scent and later a photo of a banana, and examined the reaction of the neurons. Surprisingly, nerve cells in the primary olfactory cortex responded not only to scents, but also to images. “This suggests that the task of the human olfactory cortex goes far beyond the pure perception of odours,” says co-corresponding author Prof. Marc Spehr.
The researchers discovered individual nerve cells that reacted specifically to the smell, the image and the written word of – for example – the banana. This discovery indicates that semantic information are processed early on in human olfactory processing. The results not only confirm decades of animal studies, but also show how different brain regions are involved in specific human odour processing functions. This is an important contribution to decoding the human olfactory code, says Mormann. “Further research in this area is necessary in order to one day develop olfactory aids that we can use in everyday life as naturally as glasses or hearing aids.”
